Guanabenz hydrochloride

Research use only, not for human use.

Guanabenz hydrochloride is an orally active α2-adrenoceptor agonist with hypotensive effects.

Guanabenz hydrochloride is an orally active α2-adrenoceptor agonist with hypotensive effects.

Guanabenz hydrochloride (0.5-50 μM, 24 h) is treated with increasing concentrations for 24 hours not affect cell viability.Guanabenz hydrochloride (0.5-50 μM, 24 h) alone not affects the UPR targets, neither on mRNA or protein level nor the phosphorylation status of eIF2a. Guanabenz also not induces GADD34 or the constitutively active form CReP.Guanabenz hydrochloride (0.5-50 μM, 24 h) alone not induces ER stress in neonatal rat cardiomyocytes. Cell Viability Assay Cell Line:Neonatal rat cardiac myocytes (NRCM)Concentration:0.5-50 μM Incubation Time:24 h Result:Did not affect cell survival.Western Blot Analysis Cell Line:Neonatal rat cardiac myocytes (NRCM)Concentration:0.5-50 μM Incubation Time:24 h Result:Increased the levels of low panel concentration-dependent UPR targets proteins.RT-PCR Cell Line:Neonatal rat cardiac myocytes (NRCM)Concentration:0.5-50 μM Incubation Time:24 h Result:Did not affect levels of UPR targets.

Guanabenz hydrochloride (5 mg/kg/day; i.p.; for 3 weeks) can reproducibly reduce brain cyst burden.Guanabenz hydrochloride (5 mg /kg/d, i.p., oral; 10 mg/kg/d, gavage; for 3 weeks) reverses Toxoplasma-induced hyperactivity in latently infected mice.Guanabenz hydrochloride (100 and 320 μg/kg and 1 mg/kg, i.v., over a period of 5 min at intervals of 40 min) reduces sympathetic outflow, heart rate and blood pressure in debuffered cats. Animal Model:BALB/cJ miceDosage:5 mg/kg Administration:5 mg/kg/day; i.p. ; for 3 weeks Result:Reduced the latent brain cysts in both male and female BALB/cJ mice.Animal Model:BALB/cJ mice Dosage:5 mg/kg; 10 mg/kg Administration:5 mg /kg/d, i.p., oral; 10 mg/kg/d, gavage; for 3 weeks Result:Reversed parasite-induced hyperactivity to near-baseline levels.Animal Model:Cats Dosage:100 and 320 μg/kg and 1 mg/kg Administration:100 and 320 μg/kg and 1 mg/kg, i.v., over a period of 5 min at intervals of 40 min.Result:Declined markedly blood pressure and nerve activity.

NE56490

Apoptosis

Adenosine Receptor

α2-adrenoceptor

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23113-43-1

267.54

C8H9Cl3N4

>98% (HPLC)

DMSO: Soluble

ClC1=C(C=NNC(N)=N)C(Cl)=CC=C1.[H]Cl

——

(-20℃)

With Ice Pack

≥ 2 years